Semaglutide

Description

Product Specifications

Form: Lyophilized peptide powder

Strength: Add the product-specific strength

Peptide Length: 31 amino acid residues

Peptide Classification: Synthetic modified GLP-1 analog lipopeptide research compound

Peptide Sequence: His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys*-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly

One-Letter Sequence: H-X-EGTFTSDVSSYLEGQAAK*-EFIAWLVRGRG, where X represents Aib and Lys* carries the lipid-linked side chain

Structural Modifications: Aib substitution at position 8, Arg substitution at position 34, and side-chain modification of Lys26

Lipid Modification: Lys26 is linked through a hydrophilic spacer containing γ-glutamic acid and two 8-amino-3,6-dioxaoctanoic acid units to a C18 fatty di-acid

C-Terminal Modification: Free carboxyl terminus

Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight: Approximately 4113.58 g/mol

CAS Number: 910463-68-2

Purity: ≥99%, where confirmed through batch-specific HPLC analysis

Appearance: White to off-white lyophilized peptide powder

Intended Use: Laboratory research and analytical applications only

Research Applications

Analytical characterization using HPLC, UPLC, and LC-MS workflows

In vitro investigation of GLP-1 receptor-binding behavior

Evaluation of ligand-receptor interactions under controlled assay conditions

Characterization of peptide-mediated intracellular signaling

Structure-activity analysis of modified GLP-1 analog sequences

Comparative assessment of Semaglutide and related modified research peptides

Characterization of lipid-linked peptide architecture and side-chain modifications

Peptide identity, purity, molecular weight, and structural integrity analysis

Evaluation of Aib substitution and Lys26 acylation using suitable analytical techniques

Stability profiling under controlled temperature, pH, buffer, and storage conditions

Quality Documentation

A batch-specific Certificate of Analysis and applicable analytical documentation should be available for each lot. Verify peptide identity, exact sequence, Aib8 substitution, Arg34 substitution, Lys26 lipid-linked modification, purity, molecular weight, formulation details, and batch information against the records supplied with the individual product.

The molecular formula and molecular weight listed above correspond to Semaglutide as the defined parent molecular structure. Counterion-containing, hydrated, or otherwise formulated materials may have different overall analytical characteristics. Batch-specific HPLC and mass-spectrometric documentation should therefore be used as the final reference for product specifications.

For Laboratory Research Use Only

This product is intended exclusively for controlled laboratory and in vitro research. Not for human or veterinary use. Not for diagnostic, therapeutic, clinical, cosmetic, or household applications.